Tianjin, October 23 (Reporter Zhang Daozheng) The reporter learned from Tianjin University on the 23rd that the school’s Zhang Lei and Qi Haishan teams have successfully synthesized the “mussel bionic multifunctional protein material”, which has high adhesion at the same time. Anti-bacterial, anti-fog and other functions are expected to fill the long-term gap in the medical field and become a “super coating” for medical devices and implanted devices.
The human body’s environment is sensitive and complex, and the “invaders” in vitro often react rapidly and violently. It is well known that surgical joint replacement and other operations are prone to bacterial infections. Endoscopy results in mirror water mist due to changes in temperature and humidity in the body. Implantation of devices and sensors in the body is prone to immune rejection. These have greatly affected the treatment. Effectiveness, accuracy and patient recovery.
Based on this, a coating material that can be easily and quickly adhered to the surface of a medical device and has various functions such as antifouling, antibacterial, antifogging and good biocompatibility has become a major bottleneck in the medical field.
“The mussels are everywhere in the ocean. They are sturdy and adhered to the solid surface of rocks, hulls, cables, drifting bottles, etc. under the sea. They are not eroded by dirt and microorganisms in the ocean, and can resist the erosion of wind and waves.” Inspired by the adhesion characteristics of mussels, the Zhang Lei and Qi Haishan teams of Tianjin University conducted research on the adhesion proteins of mussel foot silk. They successfully prepared the “mussel bionic multifunctional protein material” by biosynthesis.
The experimental results show that the new material has strong adhesion to a variety of medical materials, the coating produced by the material can resist more than 95% of bacteria and cell adhesion, and the antibacterial property is prominent; in the hot steam environment, the protein coating The layer-coated glass substrate still maintains high light transmittance and exhibits excellent anti-fog performance; at the same time, the protein coating also has excellent biocompatibility, the hemolysis rate is less than 0.1%, and the cell co-culture survival rate exceeds 99%. This means that medical devices coated with this protein coating are expected to overcome immune rejection in the human body.
Experts say that this “super Chinese scientists have developed a medical “super coating” with broad application
At present, the “super-coating” research of Tianjin University has applied for national patents, and the relevant results have been published in the international authoritative journals “Chemical Newsletter” and “Applied Materials and Interfaces”.